byTang, Beverly T.; Pickard, Sarah S.; Chan, Frandics P.; Tsao, Philip S.; Taylor, Charles A.; Feinstein, Jeffrey A.
This article is from Pulmonary Circulation , volume 2 . Abstract Previous clinical studies in pulmonary arterial hypertension (PAH) have concentrated predominantly on distal pulmonary vascular resistance, its contribution to the disease process, and response to therapy. However, it is well known that biomechanical factors such as shear stress have an impact on endothelial health and dysfunction in other parts of the vasculature. This study tested the hypothesis that wall shear stress is reduced... Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555417